NCIt definition : A humanized monovalent monoclonal antibody directed against the hepatocyte growth
factor receptor (c-Met) with potential antineoplastic activity. Anti-MET monoclonal
antibody MetMAb binds to the extracellular domain of c-Met, preventing the binding
of its ligand, hepatocyte growth factor (HGF); the activation of the c-Met signaling
pathway is thus inhibited, which may result in cell death in c-Met-expressing tumor
cells. c-Met, a receptor tyrosine kinase, is overexpressed on the cell surfaces of
a variety of cancer cell types and may play a key role in their proliferation, invasion
and survival.;
UNII : MS1J9720WC;
CAS number : 1133766-06-9;
Molecule name : MetMAb; OA-5D5; PRO 143966; RO5490258;