Preferred Label : Anti-Met Monoclonal Antibody Mixture Sym015;
NCIt synonyms : Hu9006-Hu9338; Hu9006/Hu9338;
NCIt definition : A mixture of two humanized immunoglobulin G1 (IgG1) monoclonal antibodies, Hu9006
and Hu9338, which recognize non-overlapping epitopes in the extracellular domain of
the human hepatocyte growth factor receptor (MET; HGFR; c-Met), with potential antineoplastic
activity. Upon administration, anti-MET monoclonal antibody mixture Sym015 targets
and binds to the extracellular domain of MET, thereby preventing the binding of its
ligand, hepatocyte growth factor (HGF). This may prevent activation of the receptor
and MET-mediated signal transduction pathways. This inhibits MET-dependent tumor cell
proliferation. MET, a receptor tyrosine kinase, is overexpressed on the cell surfaces
of various solid tumor cell types; it plays a key role in cancer cell growth, survival,
angiogenesis, invasion, and metastasis.;
Molecule name : Sym 015; Sym-015;
NCI Metathesaurus CUI : CL507929;
Origin ID : C127906;
UMLS CUI : C4287683;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
