Preferred Label : Gemnelatinib;
NCIt synonyms : c-Met Inhibitor GST-HG161;
NCIt definition : An orally bioavailable, selective inhibitor of the oncoprotein c-Met (hepatocyte growth
factor receptor; HGFR), with potential antineoplastic activity. Upon oral administration,
gemnelatinib targets and binds to c-Met protein, thereby disrupting c-Met-dependent
signal transduction pathways. This may induce cell death in tumor cells overexpressing
c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types
and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and
tumor angiogenesis.;
UNII : EFL78M2T2C;
CAS number : 2225123-30-6;
Molecule name : GST-HG161; GST HG161;
NCI Metathesaurus CUI : CL1773028;
Origin ID : C184835;
UMLS CUI : C5669573;
Semantic type(s)
- concept_is_in_subset
- has_target
