NCIt definition : A tetravalent, bispecific antibody composed of a single-chain variable fragment (scFv)
targeting epidermal growth factor receptor (EGFR) fused to the c-terminus of an immunoglobulin
G1 (IgG1) antibody targeting hepatocyte growth factor receptor (HGFR; c-Met), with
potential antineoplastic activity. Upon administration, anti-EGFR/c-Met bispecific
antibody CKD-702 simultaneously targets and binds to the extracellular domains of
wild-type or certain mutant forms of both EGFR and c-Met expressed on cancer cells,
thereby preventing receptor phosphorylation. This prevents the activation of both
EGFR- and c-Met-mediated signaling pathways. In addition, binding results in receptor
degradation, which further inhibits EGFR- and c-Met-mediated signaling, thereby inhibiting
tumor cell proliferation. EGFR and c-Met, both upregulated or mutated in a variety
of tumor cell types, play key roles in tumor cell proliferation.;
Semantic type(s)