Preferred Label : c-Met Inhibitor DO-2;
NCIt synonyms : MET Kinase Inhibitor DO-2;
NCIt definition : An orally bioavailable, brain-penetrant inhibitor of the oncoprotein c-Met (hepatocyte
growth factor receptor; HGFR), with potential antineoplastic activity. Upon oral administration,
c-Met inhibitor DO-2 targets and binds to the c-Met protein, prevents c-Met phosphorylation
and disrupts c-Met-dependent signal transduction pathways. This may induce cell death
in tumor cells overexpressing c-Met protein or expressing constitutively activated
c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types
and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and
tumor angiogenesis. The hydrogen-carbon bond(s) has been replaced with deuterium-carbon
bond(s) in DO-2 to decrease both the metabolic breakdown of the agent and the resulting
levels of inactive and toxic metabolites.;
Molecule name : DO 2; DO-2;
NCI Metathesaurus CUI : CL1906999;
Origin ID : C200165;
- concept_is_in_subset
- has_target