Preferred Label : c-Met Inhibitor SPH3348;
NCIt definition : An orally bioavailable inhibitor of the oncoprotein c-Met (hepatocyte growth factor
receptor; HGFR), with potential antineoplastic activity. Upon oral administration,
c-Met inhibitor SPH3348 targets and binds to c-Met protein, thereby disrupting c-Met-dependent
signal transduction pathways. This may induce cell death in tumor cells overexpressing
c-Met protein. c-Met protein is overexpressed or mutated in many tumor cell types
and plays key roles in tumor cell proliferation, survival, invasion, metastasis, and
tumor angiogenesis.;
Molecule name : SPH 3348; SPH-3348;
NCI Metathesaurus CUI : CL1773462;
Origin ID : C185131;
UMLS CUI : C5666948;
Semantic type(s)
- concept_is_in_subset
- has_target
