Preferred Label : Indium In 111 FPI-2071;
NCIt synonyms : 111In FPI-2071; [111In]-FPI-2071; Indium-111 FPI-2071; Indium In 111-DOTA-FPI-2053;
NCIt definition : A radioimmunoconjugate composed of FPI-2053, a humanized bispecific antibody targeting
epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (HGFR;
c-Met), conjugated to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and radiolabeled with the radioisotope indium In 111, with potential
radioimaging activity. Upon administration of indium In 111 FPI-2071, the FPI-2053
moiety targets and binds to the extracellular domains of both EGFR and c-Met expressed
on certain cancer cells, followed by internalization and retention of the radioisotope.
This allows for imaging of EGFR- and c-Met-expressing tumor cells using gamma scintigraphy.
EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play
key roles in tumor cell proliferation. EGFR and c-Met are co-expressed on the surface
of various cancer cell types while co-expression on normal, healthy cells is minimal.;
Molecule name : FPI 2071; FPI-2071;
NCI Metathesaurus CUI : CL1928973;
Origin ID : C206444;
concept_is_in_subset
- has_target
