Anti-EGFR/c-Met/c-Met Trispecific Antibody BG-T187

Preferred Label : Anti-EGFR/c-Met/c-Met Trispecific Antibody BG-T187;

NCIt synonyms : EGFR x cMET x cMET Trispecific Antibody BG-T187; Anti-EGFR x c-MET x c-MET Trispecific Antibody BG-T187; EGFRxMET Trispecific Antibody BG-T187; EGFR/cMET/cMET Trispecific Antibody BG-T187; EGFR x MET TsAb BG-T187;

NCIt definition : A trispecific antibody targeting epidermal growth factor receptor (EGFR) and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-Met trispecific antibody BG-T187 simultaneously targets and binds to the extracellular domain of both EGFR and two different epitopes of c-Met expressed on tumor cells, thereby preventing receptor phosphorylation and activation of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.;

Molecule name : BG-T187; BG T187;

Détails

Origin ID

C213107;

chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]

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