Preferred Label : Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T;
NCIt synonyms : Trispecific EGFR/cMET/cMET Antibody GB263T; EGFR x cMET x cMET Trispecific Antibody GB263T;
NCIt definition : A Fc-enhanced trispecific antibody targeting epidermal growth factor receptor (EGFR)
and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with
potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-met trispecific
antibody GB263T simultaneously targets and binds to the extracellular domain of both
EGFR and two different epitopes on c-Met expressed on tumor cells, thereby preventing
receptor phosphorylation and inducing internalization of EGFR and c-Met. This downregulates
the expression levels of both EGFR and c-Met proteins and prevents the activation
of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated
or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.;
Molecule name : GB 263T; GB-263T;
NCI Metathesaurus CUI : CL1792178;
Origin ID : C187344;
UMLS CUI : C5706409;
Semantic type(s)
- concept_is_in_subset
- has_target
