Preferred Label : AXL Inhibitor AB801;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinase AXL (UFO), with potential
immunostimulating and antineoplastic activities. Upon oral administration, AXL inhibitor
AB801 targets, reversibly binds to, and prevents the activation of AXL. This blocks
AXL-mediated signal transduction pathways, and inhibits both AXL-mediated tumor cell
growth, proliferation and migration and AXL-mediated immunosuppression. AXL, a member
of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed
by many tumor cell types and expressed in a variety of immune cells including macrophages,
natural killer (NK) cells, and regulatory T-cells (Tregs). It plays a key role in
tumor cell proliferation, survival, invasion, and metastasis, and is a mediator of
immunosuppression. Its expression is associated with drug resistance and poor prognosis.;
Molecule name : AB-801; AB 801;
NCI Metathesaurus CUI : CL1928160;
Origin ID : C205856;
concept_is_in_subset
- has_target
