Preferred Label : Mipasetamab Uzoptirine;
NCIt synonyms : Anti-AXL/PBD Antibody-drug Conjugate ADCT-601; ADC ADCT-601; Anti-AXL/PBD ADC ADCT-601;
NCIt definition : An antibody-drug conjugate (ADC), consisting of mipasetamab, a humanized immunoglobulin
(Ig) G1 monoclonal antibody directed against AXL receptor tyrosine kinase (AXL; UFO)
that is site-specifically conjugated to uzoptitine (PL1601), which contains a valine-alanine
cleavable linker and SG3199, a cytotoxic pyrrolobenzodiazepine (PBD) dimer, with potential
antineoplastic activity. Upon administration of mipasetamab uzoptirine, mipasetamab
binds to AXL, which is expressed on the surfaces of a variety of cancer cell types.
Upon endocytosis and enzymatic cleavage, SG3199 is released and forms highly cytotoxic
DNA interstrand cross-links, thereby blocking cell division and killing AXL-expressing
cancer cells. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine
kinases, is overexpressed by many tumor cell types, and plays a key role in tumor
cell proliferation, survival, invasion and metastasis; its expression is associated
with drug resistance and poor prognosis.;
UNII : 71KV7F609O;
CAS number : 2304799-73-1;
Molecule name : BGB-601; ADCT 601; ADCT-601; BGB 601;
NCI Metathesaurus CUI : CL969909;
Origin ID : C175823;
UMLS CUI : C5446770;
Semantic type(s)
- concept_is_in_subset
- has_target
