Preferred Label : Dubermatinib;
NCIt synonyms : 2-((5-Chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide;
NCIt definition : An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO),
with potential antineoplastic activity. Upon administration, dubermatinib targets
and binds to AXL and prevents its activity. This blocks AXL-mediated signal transduction
pathways and inhibits the epithelial-mesenchymal transition (EMT), which, in turn,
inhibits tumor cell proliferation and migration. In addition, TP-0903 enhances chemo-sensitivity
to certain other chemotherapeutic agents. AXL, a member of the Tyro3, AXL and Mer
(TAM) family of receptor tyrosine kinases and overexpressed by many tumor cell types,
plays a key role in tumor cell proliferation, survival, invasion and metastasis; its
expression is associated with drug resistance and poor prognosis.;
UNII : 14D65TV20J;
InChIKey : YUAALFPUEOYPNX-UHFFFAOYSA-N;
CAS number : 1341200-45-0;
Molecule name : TP-0903; TP 0903;
NCI Metathesaurus CUI : CL507906;
Origin ID : C127116;
UMLS CUI : C5139856;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
