Preferred Label : Dubermatinib Tartrate;
NCIt definition : The tartrate form of dubermatinib, an orally available and selective inhibitor of
the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon
administration, dubermatinib targets and binds to AXL and prevents its activity. This
blocks AXL-mediated signal transduction pathways and inhibits the epithelial-mesenchymal
transition (EMT), which, in turn, inhibits tumor cell proliferation and migration.
In addition, dubermatinib enhances chemo-sensitivity to certain other chemotherapeutic
agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine
kinases and overexpressed by many tumor cell types, plays a key role in tumor cell
proliferation, survival, invasion and metastasis; its expression is associated with
drug resistance and poor prognosis.;
UNII : 4E29DPH5ZG;
InChIKey : ITRNHQKFTJNXTE-WBPXWQEISA-N;
CAS number : 2305089-34-1;
NCI Metathesaurus CUI : CL1405715;
Origin ID : C171724;
UMLS CUI : C5419269;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
