Preferred Label : Enapotamab Vedotin;
NCIt synonyms : HuMax-AXL-ADC; Anti-AXL/MMAE ADC; Anti-AXL/MMAE Antibody-Drug Conjugate; Immunoglobulin G1, Anti-(Human Growth Factor Receptor axl)(Human Humax-axl Gamma1-chain),
Disulfide with Human Humax-axl Kappa-chain, Dimer Tetrakis(thioether) with Vedotin;
NCIt definition : An antibody-drug conjugate (ADC), consisting of a human monoclonal antibody directed
against AXL receptor tyrosine kinase (AXL; UFO) and conjugated, through a protease-cleavable
linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic
activity. Upon administration, the monoclonal antibody moiety of enapotamab vedotin
binds to AXL, which is expressed on the surfaces of a variety of cancer cell types.
Upon endocytosis and enzymatic cleavage, MMAE is released into the tumor cell cytosol,
where it binds to tubulin and inhibits tubulin polymerization; this may result in
G2/M phase arrest and apoptosis. AXL, a member of the TAM (TYRO3, AXL and MER) family
of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key
role in tumor cell proliferation, survival, invasion and metastasis; its expression
is associated with drug resistance and poor prognosis.;
UNII : 43HH4XYH2N;
CAS number : 1912424-97-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1912424-97-5
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G-SRS /a ;
NCI Metathesaurus CUI : CL520570;
Origin ID : C132017;
UMLS CUI : C5235394;
Semantic type(s)
- concept_is_in_subset
- has_target
