Preferred Label : AXL Inhibitor DS-1205c;
NCIt definition : An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO),
with potential antineoplastic activity. Upon administration, DS-1205c targets, binds
to and prevents the activation of AXL. This blocks AXL-mediated signal transduction
pathways and inhibits tumor cell proliferation and migration. AXL, a member of the
Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by
many tumor cell types. It plays a key role in tumor cell proliferation, survival,
invasion and metastasis; its expression is associated with drug resistance and poor
prognosis.;
Molecule name : DS 1205c; DS-1205c;
NCI Metathesaurus CUI : CL554179;
Origin ID : C152976;
UMLS CUI : C4726994;
Semantic type(s)
- concept_is_in_subset
- has_target
