Preferred Label : Gilteritinib;
NCIt synonyms : 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-like
tyrosine kinase 3 (FLT3; STK1; FLK2), AXL (UFO; JTK11), anaplastic lymphoma kinase
(ALK; CD246), and leukocyte receptor tyrosine kinase (LTK), with potential antineoplastic
activity. Upon administration, gilteritinib binds to and inhibits both the wild-type
and mutated forms of FLT3, AXL, ALK and LTK. This may result in an inhibition of FLT3-,
AXL-, ALK-, and LTK-mediated signal transduction pathways and reduced proliferation
in cancer cells that overexpress these RTKs. FLT3, AXL, ALK, and LTK, which are overexpressed
or mutated in a variety of cancer cell types, play key roles in tumor cell growth
and survival.;
UNII : 66D92MGC8M;
InChIKey : GYQYAJJFPNQOOW-UHFFFAOYSA-N;
CAS number : 1254053-43-4;
Molecule name : ASP-2215; ASP 2215;
Codes from synonyms : 245;
Origin ID : C116722;
UMLS CUI : C3896940;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
