Preferred Label : Tamnorzatinib;
NCIt synonyms : Axl/Mer RTK Inhibitor ONO-7475; Axl/Mer Inhibitor ONO-7475;
NCIt definition : An orally available and selective inhibitor of the receptor tyrosine kinases (RTKs)
Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, tamnorzatinib
targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl-
and Mer-mediated signal transduction pathways, and inhibits proliferation and migration
of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3,
Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play
key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis,
and their expression is associated with drug resistance and poor prognosis.;
UNII : 0VCB95RHRV;
CAS number : 1646839-59-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1646839-59-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : ONO 7475; ONO-7475;
NCI Metathesaurus CUI : CL524653;
Origin ID : C136822;
UMLS CUI : C5783368;
Semantic type(s)
- concept_is_in_subset
- has_target
