Tyrosine-Protein Kinase Mer

Preferred Label : Tyrosine-Protein Kinase Mer;

NCIt synonyms : c-mer Proto-oncogene Tyrosine Kinase; MERTK; Receptor Tyrosine Kinase-MERTK; Proto-Oncogene c-Mer; Receptor Tyrosine Kinase MerTK; EC 2.7.10.1;

NCIt definition : Tyrosine-protein kinase Mer (999 aa, 110 kDa) is encoded by the human MERTK gene. This protein is involved in ligand-dependent signaling.;

Details

Origin ID

C26383;

UMLS CUI

C1259418;

OMIM relation
- Mer tyrosine kinase protooncogene [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- MERTK protein, human [MeSH concept]
- MERTK protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MERTK Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phagocytosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Axl/Mer Inhibitor INCB081776 [NCIt concept]
- Axl/Mer Inhibitor PF-07265807 [NCIt concept]
- Axl/Mer/CSF1R Inhibitor Q702 [NCIt concept]
- TAM/c-Met Inhibitor RXDX-106 [NCIt concept]
- Tamnorzatinib [NCIt concept]
- Zanzalintinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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