Preferred Label : Axl/Mer Inhibitor INCB081776;
NCIt definition : An orally available and selective inhibitor of the receptor tyrosine kinases (RTKs)
Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, INCB081776
targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl-
and Mer-mediated signal transduction pathways, and inhibits proliferation and migration
of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3,
Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play
key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis,
and their expression is associated with enhanced immunosuppression, drug resistance
and poor prognosis.;
Molecule name : INCB-081776; INCB 081776; INCB 81776; INCB-81776;
NCI Metathesaurus CUI : CL554380;
Origin ID : C153122;
UMLS CUI : C4727040;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
