Conteltinib - CISMeF

Preferred Label : Conteltinib;

NCIt synonyms : ALK/FAK/Pyk2 Inhibitor CT-707;

NCIt definition : An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), with potential antineoplastic activity. Upon administration, conteltinib selectively binds to and inhibits ALK , FAK and Pyk2. The inhibition leads to disruption of ALK- , FAK- and Pyk2-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK-, FAK- and Pyk2-overexpressing tumor cells. Expression of these tyrosine kinases is dysregulated in various tumor types; they play a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis.;

UNII : URX2UMQ8XV;

InChIKey : NPJCURIANJMFEO-UHFFFAOYSA-N;

CAS number : 1384860-29-0;

Molecule name : CT 707; CT-707;

NCI Metathesaurus CUI : CL1382218;

Details

Origin ID

C169863;

UMLS CUI

C5418334;

Currated CISMeF NLP mapping
- conteltinib [MeSH Supplementary Concept]
- conteltinib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- conteltinib [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ALK Tyrosine Kinase Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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