Alectinib - CISMeF

Preferred Label : Alectinib;

NCIt synonyms : 5H-benzo(b)carbazole-3-carbonitrile, 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-(4-(4-morpholinyl)-1-piperidinyl)-11-oxo-; ALK Inhibitor RO5424802;

NCIt definition : An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, alectinib binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.;

UNII : LIJ4CT1Z3Y;

InChIKey : KDGFLJKFZUIJMX-UHFFFAOYSA-N;

CAS number : 1256580-46-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1256580-46-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Alecensa;

Molecule name : CH5424802; AF-802; RO5424802; RG7853;

ChEBI ID : CHEBI:62268;

Codes from synonyms : 16;

Details

Origin ID

C101790;

UMLS CUI

C3853921;

Automatic exact mappings (from CISMeF team)
- Alectinib [ICD-11 Extension code]
- alectinib [ATC Code]
Currated CISMeF NLP mapping
- alectinib [MeSH concept]
- alectinib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing alectinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alectinib (substance) [SNOMED CT concept]
- Product containing alectinib (medicinal product) [SNOMED CT concept]
- alectinib [MeSH concept]
- alectinib [MeSH Supplementary Concept]
- alectinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ALK Tyrosine Kinase Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Alectinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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