Utatrectinib - CISMeF

Preferred Label : Utatrectinib;

NCIt synonyms : TRK Inhibitor AZD7451; Tropomyosin Receptor Kinase Inhibitor AZD7451;

NCIt definition : A tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. Upon administration, utatrectinib binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival.;

UNII : VNM956Y27V;

CAS number : 1079274-94-4;

Molecule name : AZD7451;

Details

Origin ID

C99161;

UMLS CUI

C5708924;

Currated CISMeF NLP mapping
- AZD7451 [MeSH concept]
- AZD7451 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AZD7451 [MeSH concept]
- AZD7451 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- BDNF/NT-3 Growth Factors Receptor [NCIt concept]
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- NT-3 Growth Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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