Thyroid Gland Medullary Carcinoma

Preferred Label : Thyroid Gland Medullary Carcinoma;

NCIt synonyms : Medullary Carcinoma of Thyroid; Medullary Thyroid Gland Carcinoma; Medullary Carcinoma of the Thyroid; Medullary Thyroid Carcinoma; Medullary Carcinoma of the Thyroid Gland; Medullary Thyroid Cancer; Thyroid Gland Neuroendocrine Carcinoma; C-Cell Carcinoma;

NCIt related terms : Thyroid Gland Medullary Cancer; Medullary Carcinoma of Thyroid Gland; C cell carcinoma; Medullary Carcinoma; MTC; Parafollicular cell carcinoma; Thyroid Medullary Carcinoma; CARCINOMA, C-CELL, MALIGNANT;

NCIt definition : A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.;

Alternative definition : NCI-GLOSS: Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood.; NICHD: Carcinoma arising from the C-cells of the thyroid gland.; CDISC: A neuroendocrine malignant epithelial neoplasm arising from C-cells of the thyroid gland.;

Neoplastic status : Malignant;

Codes from synonyms : CDR0000044550; 10027105;

Details

Origin ID

C3879;

UMLS CUI

C0238462;

Currated CISMeF NLP mapping
- Medullary carcinoma of thyroid [MedDRA LLT]
- Medullary carcinoma of thyroid gland [ICD-11 Subcategory]
- Medullary thyroid cancer [MedDRA Preferred Term]
- Medullary thyroid carcinoma [ICD-11 Extension code]
- Medullary thyroid carcinoma [HPO term]
- Medullary thyroid carcinoma [ORDO Disease]
- Medullary thyroid carcinoma (disorder) [SNOMED CT concept]
- Parafollicular cell carcinoma (disorder) [SNOMED CT concept]
- Thyroid carcinoma, familial medullary [OMIM Phenotype]
- medullary thyroid carcinoma [Disease (Nov.)]
- thyroid cancer, medullary [MeSH concept]
- thyroid cancer, medullary [MeSH Supplementary Concept]
- thyroid gland medullary carcinoma [DO Concept]
DO Cross reference
- thyroid gland medullary carcinoma [DO Concept]
Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Cold Nodule [NCIt concept]
- Metastatic Malignant Neoplasm in the Lymph Nodes [NCIt concept]
- Organoid Pattern [NCIt concept]
- Trabecular Pattern [NCIt concept]
Excludes anatomical site(s)
- Lung [NCIt concept]
- Pituitary Gland [NCIt concept]
False automatic mappings
- Medicine, Chinese Traditional [DeCS]
- Medullary carcinoma [PASCAL descriptor]
- Medullary carcinoma (morphologic abnormality) [SNOMED CT concept]
- Medullary carcinoma, NOS [ICD-O code]
- carcinoma, medullary [MeSH Descriptor]
- carcinoma, medullary [MeSH concept]
- medullary carcinoma [Disease (Nov.)]
- medullary carcinoma [Radlex concept]
- medullary carcinoma, nos [SNOMED Notion]
HPO term
- Medullary thyroid carcinoma [HPO term]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
- Thyroid Gland [NCIt concept]
See also inter- (CISMeF)
- neurotrophic receptor tyrosine kinase 1 [ORDO Gene]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Medullary carcinoma of thyroid [MedDRA LLT]
- Medullary thyroid cancer [MedDRA Preferred Term]
- Medullary thyroid carcinoma [ORDO Disease]
- Medullary thyroid carcinoma [HPO term]
- Medullary thyroid carcinoma (disorder) [SNOMED CT concept]
- Parafollicular cell carcinoma (disorder) [SNOMED CT concept]
- medullary thyroid carcinoma [Disease (Nov.)]
- thyroid cancer, medullary [MeSH Supplementary Concept]
- thyroid cancer, medullary [MeSH concept]
- thyroid gland medullary carcinoma [DO Concept]
associated_with_malfunction_of_gene_product
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- High Affinity Nerve Growth Factor Receptor Isoform TrkA-III [NCIt concept]
concept_is_in_subset
- CDISC SEND Terminology [NCIt concept]
- CDISC SEND Tumor Findings Results Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Thyroid Cancer Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Endocrinology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Endocrine Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Neuroendocrine Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_associated_gene
- Oncogene RET [NCIt concept]
disease_has_finding
- Calcitonin Positive Neoplastic Cells Present [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
- Serum Calcitonin Level Increased [NCIt concept]
- Well-Circumscribed Lesion [NCIt concept]
disease_has_molecular_abnormality
- Activating RET Gene Mutation [NCIt concept]
disease_has_normal_cell_origin
- C-Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Thyroid Gland Epithelial Tissue [NCIt concept]
- Thyroid Gland Follicle [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Neck [NCIt concept]
- Thyroid Gland [NCIt concept]
disease_mapped_to_gene
- RET Gene [NCIt concept]
disease_may_have_abnormal_cell
- Malignant Neuroendocrine Polygonal Cell [NCIt concept]
- Malignant Neuroendocrine Small Round Cell [NCIt concept]
- Malignant Neuroendocrine Spindle Cell [NCIt concept]
disease_may_have_associated_disease
- Paraneoplastic Syndrome [NCIt concept]
pathogenesis_of_disease_involves_gene
- RET Gene [NCIt concept]
- RET wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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