High Affinity Nerve Growth Factor Receptor Isoform TrkA-III

Preferred Label : High Affinity Nerve Growth Factor Receptor Isoform TrkA-III;

NCIt synonyms : TrkAIII; Tyrosine Kinase Receptor A Isoform TrkA-III; Tyrosine Kinase Receptor Isoform TrkA-III; Nerve Growth Factor Receptor Type 1 Isoform TrkA-III; TrkA-III; NTRK1 Isoform TrkA-III; EC 2.7.10.1; Neurotrophic Tyrosine Kinase Receptor Type 1 Isoform TrkA-III; Tropomyosin-Related Kinase A Isoform TrkA-III;

NCIt definition : High affinity nerve growth factor receptor isoform TrkA-III (698 aa, 77 kDa) is encoded by the human NTRK1 gene. This protein is involved in constitutive signaling and tyrosine phosphorylation.;

NCIt note : High affinity nerve growth factor receptor isoform TrkA-III is missing the first Ig-like C2-type domain (via a substitution of amino acid residues 192-284 with a valine) and amino acids 393-398. This isoform is constitutively active and does not bind NGF and does not interact with the adaptor molecules GRB2 and FRS2. (UniProt); High Affinity Nerve Growth Factor Receptor Isoform TrkA-III isoform is specifically expressed by pluripotent neural stem and neural crest progenitors and its expression is stimulated by hypoxia. (UniProt);

Details

Origin ID

C105368;

UMLS CUI

C3538924;

OMIM relation
- Neurotrophic tyrosine kinase, receptor, type 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- NTRK1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
- NTRK Family Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Thyroid Gland Medullary Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Neural Development [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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