Preferred Label : Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate;
NCIt synonyms : PLX7486-TsOH;
NCIt definition : The tosylate salt form of PLX7486, a selective inhibitor of the receptor tyrosine
kinases colony-stimulating factor-1 receptor (CSF1R; fms) and neurotrophic tyrosine
kinase receptor types 1, 2 and 3 (TrkA, TrkB, and TrkC, respectively) with potential
antineoplastic activity. Upon administration, PLX7486 binds to and inhibits the activity
of these tyrosine kinases. This inhibits Fms and Trk-mediated signaling transduction
pathways that are upregulated in certain cancer cell types. This may eventually halt
tumor cell proliferation in Fms and TrkA, TrkB, and/or TrkC-overexpressing tumor cells.
Fms and TrkA, TrkB, and TrkC are receptor tyrosine kinases that are upregulated or
mutated in a variety of tumors and promote tumor cell proliferation and survival.;
Origin ID : C105804;
UMLS CUI : C3830093;
Semantic type(s)
- concept_is_in_subset
- has_target
