Preferred Label : TrkA Inhibitor VMD-928;
NCIt synonyms : NTRK1 Inhibitor VMD-928;
NCIt related terms : VMD-928;
NCIt definition : An orally bioavailable, selective inhibitor of tropomyosin receptor kinase A (TrkA;
neurotrophic tyrosine receptor kinase (NTRK) type 1; NTRK1; TRK1-transforming tyrosine
kinase protein), with potential antineoplastic activity. Upon oral administration,
VMD-928 specifically targets and binds to TrkA, inhibits neurotrophin-TrkA interaction
and prevents TrkA activation. This prevents the activation of downstream signaling
pathways and inhibits cell growth in tumors that overexpress TrkA. Uncontrolled TrkA
signaling plays an important role in tumor cell growth, survival, invasion and treatment
resistance.;
UNII : 1JT6DVS51P;
CAS number : 1802770-18-8;
Molecule name : VMD-928; VMD 928;
NCI Metathesaurus CUI : CL554374;
Origin ID : C153116;
UMLS CUI : C4727034;
Semantic type(s)
- concept_is_in_subset
- has_target
