G2/Mitotic-Specific Cyclin-B2

Preferred Label : G2/Mitotic-Specific Cyclin-B2;

NCIt synonyms : Cyclin B2; CCNB2; G2/Mitotic-Specific Cyclin B2; Cyclin-B2;

NCIt definition : G2/mitotic-specific cyclin-B2 (398 aa, 45 kDa) is encoded by the human CCNB2 gene. This protein plays a role in the regulation of the progression of the cell cycle from G2 to mitosis.;

NCIt note : Cyclin B2 interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex, activating and imparting substrate specificity to the complex. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/CDC2 may play a key role in transforming growth factor beta-mediated cell cycle control. Cyclin B2 accumulates steadily during G2 and is abruptly destroyed at mitosis. Overexpression of cyclins B, resulting from different mechanisms, could contribute, through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer.;

Details

Origin ID

C25773;

UMLS CUI

C1609830;

Currated CISMeF NLP mapping
- cyclin B2 [MeSH Descriptor]
- cyclin B2 [MeSH concept]
OMIM relation
- Cyclin b2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCNB2 protein, human [MeSH Supplementary Concept]
- CCNB2 protein, human [MeSH concept]
- cyclin B2 [MeSH concept]
- cyclin B2 [MeSH Descriptor]
gene_encodes_gene_product
- CCNB2 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Golgi Apparatus [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- Cyclin B [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- EFP Cell Cycle Pathway [NCIt concept]
gene_product_is_physical_part_of
- M-Phase Promoting Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Mitotic/Spindle Checkpoint [NCIt concept]

Keyword's position in hierarchy(ies) :

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