Dinaciclib - CISMeF

Preferred Label : Dinaciclib;

NCIt synonyms : 2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5- a]pyrimidin-5-yl]-, (2S)-;

NCIt related terms : CDK inhibitor SCH 727965;

NCIt definition : A pyrazolo[1,5-a]pyrimidine with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9; inhibition of CDK1 and CDK2 may result in cell cycle repression and tumor cell apoptosis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of advanced melanoma (a type of skin cancer) and other types of cancer. It blocks cell division and may cause cancer cells to die. It is a type of cyclin-dependent kinase inhibitor.;

UNII : 4V8ECV0NBQ;

InChIKey : PIMQWRZWLQKKBJ-SFHVURJKSA-N;

CAS number : 779353-01-4;

Molecule name : SCH 727965; MK-7965; MK 7965; SCH-727965;

Chemical formula : C21H28N6O2;

Codes from synonyms : CDR0000662959; CDR0000662958; 160;

Details

Origin ID

C78854;

UMLS CUI

C2698720;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dinaciclib [MeSH Supplementary Concept]
- dinaciclib [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 5 [NCIt concept]
- Cyclin-Dependent Kinase 9 [NCIt concept]

Keyword's position in hierarchy(ies) :

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