CDK1/2/4 Inhibitor AG-024322

Preferred Label : CDK1/2/4 Inhibitor AG-024322;

NCIt related terms : AG-24322;

NCIt definition : A cyclin-dependent kinase (CDK) inhibitor with antineoplastic activity. AG-024322 selectively inhibits cyclin-dependent kinases (particularly CDK1,2 and 4), enzymes that regulate cell cycle progression. Inhibition of CDK may result in cell cycle arrest, induction of apoptosis, and inhibition of DNA replication and tumor cell proliferation.;

UNII : 926F8X7TNO;

CAS number : 837364-57-5;

Molecule name : AG-024322; AG-24322;

Details

Origin ID

C52182;

UMLS CUI

C4519289;

Currated CISMeF NLP mapping
- AG 024322 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AG 024322 [MeSH concept]
Validated automatic mappings to NTBT
- N-((5-(3-(4,6-difluoro-1H-benzimidazol-2-yl)-1H-indazol-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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