CDC25 and CHK1 Regulatory Pathway

Preferred Label : CDC25 and CHK1 Regulatory Pathway;

NCIt related terms : cdc25 and chk1 Regulatory Pathway in response to DNA damage;

Alternative definition : BIOCARTA: Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_cdc25Pathway;

Details

Origin ID

C39020;

UMLS CUI

C1511426;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 1 [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- Wee1-Like Protein Kinase [NCIt concept]
pathway_has_gene_element
- ATM wt Allele [NCIt concept]
- CDK1 wt Allele [NCIt concept]
- CHEK1 wt Allele [NCIt concept]
- RASGRF1 wt Allele [NCIt concept]
- WEE1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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