Wee1-Like Protein Kinase

Preferred Label : Wee1-Like Protein Kinase;

NCIt synonyms : WEE1hu; Wee1A Kinase; EC 2.7.10.2;

NCIt definition : Wee1-like protein kinase (646 aa, 72 kDa) is encoded by the human WEE1 gene. This protein plays a role in cell cycle progression and protein phosphorylation.;

NCIt note : Wee1-like protein kinase plays a role in G2/M checkpoint control. This function makes it an attractive target for development of agonists to be part of cancer therapeutic regimens.;

Details

Origin ID

C92677;

UMLS CUI

C1506818;

OMIM relation
- Wee1 g2 checkpoint kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- WEE1 protein, human [MeSH concept]
- WEE1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- WEE1 Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- CDC25 and CHK1 Regulatory Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- G2 to M Transition Process [NCIt concept]
- Mitosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Adavosertib [NCIt concept]
- Azenosertib [NCIt concept]
- Wee1 Inhibitor [NCIt concept]
- Wee1 Kinase Inhibitor Debio 0123 [NCIt concept]
- Wee1 Kinase Inhibitor IMP7068 [NCIt concept]

Keyword's position in hierarchy(ies) :

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