TP73 wt Allele

Preferred Label : TP73 wt Allele;

NCIt synonyms : Tumor Protein p73 wt Allele; TRP73, Mouse, Homolog of Gene;

NCIt definition : Human TP73 wild-type allele is located in the vicinity of 1p36.33 and is approximately 1 kb in length. This allele, which encodes tumor protein p73, plays a role in the cell cycle and is frequently deleted in neuroblastoma and other cancers.;

NCIt note : The tumor suppressor TP73 gene encodes a 73 kD protein with sequence similarity to p53. p53 residues implicated in DNA binding are conserved in p73, which appears to activate some p53-responsive genes and to induce apoptosis. p73 and c-ABL may participate in a mismatch repair-dependent pro-apoptotic signaling pathway. T-cells undergoing TCR-AICD, in a late G1 cell-cycle checkpoint, are dependent on E2F1 and TP73. Expression of E2F1 causes accumulation of p73.;

GenBank Accession Number : Y11416; NM_005427;

Details

Origin ID

C49424;

UMLS CUI

C1710313;

OMIM relation
- Tumor protein p73 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Neuroblastoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 3592286-3673013 [NCIt concept]
gene_in_chromosomal_location
- 1p36 [NCIt concept]
gene_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- DNA Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients