Tumor Protein p73

Preferred Label : Tumor Protein p73;

NCIt synonyms : TP73; p53-Like Transcription Factor; p53-Related Protein p73; p53-Related Protein; P73; TP73 Protein;

NCIt definition : Tumor protein p73 (636 aa, 70 kDa) is encoded by the human TP73 gene. This protein is involved in the regulation of transcription, DNA damage response and apoptosis.;

NCIt note : The TP73 protein is the product of a tumor suppressor gene that encodes a protein with sequence similarity to p53; the p53 residues implicated in DNA binding are conserved in p73, which appears to activate some p53-responsive genes and to induce apoptosis. p73 and c-ABL may participate in a mismatch repair-dependent pro-apoptotic signaling pathway. p73 and c-ABL associate through interaction of a c-ABL SH3 domain with a p73 PXXP motif in the C-terminal homooligomerization domain. p73 is a c-ABL kinase substrate; p73 phosphorylation is enhanced by gamma-irradiation. c-ABL stimulates p73-mediated transactivation and apoptosis. T-cells undergoing TCR-AICD, which occurs at a late G1 cell-cycle checkpoint, is dependent on E2F1 and TP73. Expression of E2F1 causes accumulation of p73. (from OMIM 601990);

Details

Origin ID

C18577;

UMLS CUI

C0919517;

OMIM relation
- Tumor protein p73 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TP73 protein, human [MeSH Supplementary Concept]
- TP73 protein, human [MeSH concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TP73 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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