Preferred Label : ATM Inhibitor M 3541;
NCIt synonyms : Ataxia Telangiectasia Mutated Kinase Inhibitor M 3541;
NCIt definition : An orally bioavailable inhibitor of ataxia telangiectasia mutated kinase (ATM), with
potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration,
M 3541 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and
ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA
damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing
tumor cells. In addition, M 3541 sensitizes tumor cells to chemo- and radiotherapy.
ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell
types; it is activated in response to DNA damage and plays a key role in DNA-strand
repair.;
Molecule name : M 3541; M3541;
NCI Metathesaurus CUI : CL525064;
Origin ID : C138076;
UMLS CUI : C4527368;
Semantic type(s)
- concept_is_in_subset
- has_target
