Metalloproteinase Inhibitor 3

Preferred Label : Metalloproteinase Inhibitor 3;

NCIt synonyms : TIMP-3; Protein MIG-5; Tissue Inhibitor of Metalloproteinases 3; K222 Expressed in Degenerative Retinas; MIG-5 Protein; Tissue Inhibitor of Metalloproteinase-3;

NCIt definition : Metalloproteinase inhibitor 3 (221aa, 24 kDa) is encoded by the human TIMP3 gene. This protein is involved in metalloproteinase inhibition.;

NCIt note : Protein_Malfunction_Associated_With_Disease: Sorsby Fundus Dystrophy; Protein_Expressed_In_Tissue: Widely Expressed; Protein_Family: TIMP Family; Protein_Interacts_With: MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14, MMP-15; Protein_Plays_Role_In_Biological_Process: Connective Tissue Remodeling;

Details

Origin ID

C17681;

UMLS CUI

C1527365;

Currated CISMeF NLP mapping
- tissue inhibitor of Metalloproteinase-3 [MeSH concept]
- tissue inhibitor of metalloproteinase-3 [MeSH Descriptor]
OMIM relation
- Tissue inhibitor of metalloproteinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TIMP3 protein, human [MeSH Supplementary Concept]
- TIMP3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TIMP3 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Inhibitory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Inhibition of Matrix Metalloproteinases Pathway [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Enzyme Inhibition [NCIt concept]
- Protein Degradation Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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