Proliferating Cell Nuclear Antigen

Preferred Label : Proliferating Cell Nuclear Antigen;

NCIt synonyms : PCNA; Cyclin; DNA Polymerase Delta Auxiliary Protein;

NCIt definition : Proliferating cell nuclear antigen (261 aa, 29 kDa) is encoded by the human PCNA gene. This protein is involved in the regulation of both DNA replication and DNA mismatch repair.;

NCIt note : This protein is found in the nucleus and is a cofactor of DNA polymerase delta. It acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (LocusLink);

NCI Metathesaurus CUI : CL964499;

Details

Origin ID

C17323;

UMLS CUI

C4743287;

Automatic exact mappings (from CISMeF team)
- Cyclin a2 [OMIM gene]
- PCNA extractable nuclear [LOINC component]
- Proliferating cell nuclear antigen [OMIM gene]
- cyclin A [MeSH concept]
- cyclin a [MeSH Descriptor]
- cyclin b [MeSH Descriptor]
- cyclin e [MeSH Descriptor]
- cyclin-dependent protein serine/threonine kinase regulator activity [GO term]
- proliferating cell nuclear antigen [ORDO Gene]
- proliferating cell nuclear antigen [HGNC gene]
Currated CISMeF NLP mapping
- cyclins [MeSH concept]
- proliferating cell nuclear antigen [MeSH Descriptor]
- proliferating cell nuclear antigen [MeSH concept]
False automatic mappings
- cyclins [MeSH Descriptor]
- obsolete proliferating cell nuclear antigen [GO term]
OMIM relation
- Proliferating cell nuclear antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PCNA protein, human [MeSH Supplementary Concept]
- proliferating cell nuclear antigen [MeSH concept]
- proliferating cell nuclear antigen [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- DNA Repair Gene [NCIt concept]
- PCNA Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_biomarker_type
- Proliferation Marker [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- p53 Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Repair [NCIt concept]
- DNA Synthesis [NCIt concept]
is_target
- APIM-containing Peptide ATX-101 [NCIt concept]
- PCNA Inhibitor AOH1996 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients