Preferred Label : PCNA Inhibitor AOH1996;
NCIt synonyms : Proliferating Cell Nuclear Antigen Inhibitor AOH1996;
NCIt definition : An orally bioavailable, small molecule inhibitor of proliferating cell nuclear antigen
(PCNA), with potential chemo-sensitizing and antineoplastic activities. Upon oral
administration, PCNA inhibitor AOH1996 penetrates cells and targets and binds to PCNA,
preventing the binding of PCNA's interacting proteins to PCNA. This disrupts the interactions
between PCNA and these proteins and may result in DNA replication stress and inhibition
of DNA repair, which may enhance the efficacy of some antineoplastic agents and induce
apoptosis. PCNA is a scaffold protein involved in multiple cellular processes via
its interactions with many proteins.;
Molecule name : AOH 1996; AOH-1996;
NCI Metathesaurus CUI : CL1773490;
Origin ID : C185144;
UMLS CUI : C5666951;
Semantic type(s)
- concept_is_in_subset
- has_target
