proliferating cell nuclear antigen

Preferred Label : proliferating cell nuclear antigen;

MeSH definition : Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.;

MeSH synonym : antigen, proliferating cell nuclear; pcna;

CISMeF synonym : pcna-cyclin; pcna cyclin;

Wikipedia link : https://en.wikipedia.org/wiki/Proliferating cell nuclear antigen;

Is substance : O;

Details

Origin ID

D018809;

UMLS CUI

C0072108;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Proliferating Cell Nuclear Antigen [NCIt concept]
Indexing information
- PAF protein, mouse [MeSH Supplementary Concept]
Record concept(s)
- proliferating cell nuclear antigen [MeSH concept]
Related MeSH Supplementary Concept(s)
- PCN-1 protein, C elegans [MeSH Supplementary Concept]
- PCNA protein, human [MeSH Supplementary Concept]
- PCNA1 antigen, Arabidopsis [MeSH Supplementary Concept]
- PCNA2 antigen, Arabidopsis [MeSH Supplementary Concept]
- POL30 protein, S cerevisiae [MeSH Supplementary Concept]
- p27 antigen [MeSH Supplementary Concept]
- proliferating cell nuclear antigen p145 [MeSH Supplementary Concept]
See also inter- (CISMeF)
- PCNA extractable nuclear [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Peripheral cell nuclear antigen (substance) [SNOMED CT concept]
- Proliferating Cell Nuclear Antigen [NCIt concept]

Keyword's position in hierarchy(ies) :

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