Preferred Label : Ebvaciclib;
NCIt synonyms : CDK Inhibitor PF-06873600;
NCIt definition : An orally bioavailable, cyclin dependent kinase (CDK) inhibitor, with potential antineoplastic
activity. Upon administration, ebvaciclib selectively targets, binds to and inhibits
the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, an induction
of apoptosis, and inhibition of tumor cell proliferation. CDKs are ATP-dependent serine/threonine
kinases that are important regulators of cell cycle progression and proliferation
and are frequently overexpressed in tumor cells.;
UNII : 3B512HJD65;
InChIKey : QIEKHLDZKRQLLN-FOIQADDNSA-N;
CAS number : 2185857-97-8;
Molecule name : PF 06873600; PF-06873600;
NCI Metathesaurus CUI : CL553210;
Origin ID : C151988;
UMLS CUI : C5446327;
Semantic type(s)
- concept_is_in_subset
- has_target
