Preferred Label : Certociclib;
NCIt synonyms : CDK2 Inhibitor BLU-222;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential
antineoplastic activity. Upon administration, certociclib selectively targets, binds
to and inhibits the activity of CDK2. This may lead to cell cycle arrest, the induction
of apoptosis, and the inhibition of tumor cell proliferation. CDK2, a serine/threonine
kinase that plays an important role in the regulation of cell cycle progression and
cellular proliferation, is overexpressed in certain tumor cells.;
UNII : U93X72ED47;
CAS number : 2888704-84-3;
Molecule name : BLU-222; BLU 222;
NCI Metathesaurus CUI : CL1792897;
Origin ID : C188045;
UMLS CUI : C5706443;
Semantic type(s)
- concept_is_in_subset
- has_target
