Preferred Label : CDK2 Inhibitor NKT3447;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential
antineoplastic activity. Upon oral administration, CDK2 inhibitor NKT3447 selectively
targets, reversibly binds to and inhibits the activity of CDK2. This blocks G1/S cell
cycle transition, which leads to cell cycle arrest, the induction of apoptosis, and
the inhibition of tumor cell proliferation. CDK2, a serine/threonine kinase that plays
an important role in the regulation of cell cycle progression and cellular proliferation,
is overexpressed in certain tumor cells.;
Molecule name : NKT 3447; NKT-3447;
NCI Metathesaurus CUI : CL1926966;
Origin ID : C204754;
UMLS CUI : C5908055;
Semantic type(s)
- concept_is_in_subset
- has_target
