Cyclin-Dependent kinase 2

Preferred Label : Cyclin-Dependent kinase 2;

MeSH definition : A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.;

MeSH synonym : cdk2 protein kinase; p33cdk2 kinase; cdk2 protein; cdc2-related protein kinase; cdc2 related protein kinase; cyclin dependent kinase 2;

CISMeF synonym : EC 2.7.1.37;

Registry Number MeSH : EC 2.7.11.22;

Wikipedia link : https://en.wikipedia.org/wiki/Cyclin dependent kinase 2;

Is substance : O;

UNII : EC 2.7.11.22;

Details

Origin ID

D051357;

UMLS CUI

C1533646;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cyclin-Dependent Kinase 2 [NCIt concept]
Indexing information
- 3-(7-(benzylamino)-3-isopropylpyrazolo(1,5-a)pyrimidin-5-ylamino)-1,2,4-butanetriol [MeSH Supplementary Concept]
- N-(((1,2-dicyano-2-(((4-methoxyphenyl)methylene)amino)vinyl)amino)carbonyl)-4-methylbenzenesulfonamide [MeSH Supplementary Concept]
- N-((5-(3-(4,6-difluoro-1H-benzimidazol-2-yl)-1H-indazol-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine [MeSH Supplementary Concept]
- NU6102 [MeSH Supplementary Concept]
Record concept(s)
- Cyclin-Dependent kinase 2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CDK2 protein, human [MeSH Supplementary Concept]
- Cdk2 protein, mouse [MeSH Supplementary Concept]
- Cdk2 protein, rat [MeSH Supplementary Concept]
- Cdk2 protein, xenopus [MeSH Supplementary Concept]
- cdc2rk protein, drosophila [MeSH Supplementary Concept]
- cdk2 protein, Drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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