Preferred Label : CDK2 Inhibitor INCB123667;
NCIt synonyms : CDK2 Kinase Inhibitor INCB123667;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential
antineoplastic activity. Upon oral administration, CDK2 inhibitor INCB123667 selectively
targets, binds to and inhibits the activity of CDK2. This inhibits retinoblastoma
(Rb) phosphorylation and blocks G1/S transition, which leads to cell cycle arrest,
the induction of apoptosis, and the inhibition of tumor cell proliferation. CDK2,
in complex with cyclin E1 (CCNE1; CCNE-1), phosphorylates Rb, which leads to E2F target
gene expression and G1 to S-phase cell cycle progression. CDK2 and CCNE1 are overexpressed
in various tumor cell types.;
Molecule name : INCB-123667; INCB 123667;
Origin ID : C212984;
concept_is_in_subset
- has_target
