" /> Enitociclib - CISMeF





Preferred Label : Enitociclib;

NCIt synonyms : PTEF-b/CDK9 Inhibitor BAY1251152; PTEF-b/CDK9 Inhibitor VIP152;

NCIt definition : An inhibitor of cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF- b; PTEFb), with potential antineoplastic activity. Upon administration, enitociclib binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation. The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.;

UNII : 1255AT22ZJ;

CAS number : 1610408-97-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1610408-97-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BAY1251152; BAY 1251152; VIP-152; VIP 152;

NCI Metathesaurus CUI : CL507865;

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13/05/2024


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