Preferred Label : CDK2/4/6/FLT3 Inhibitor FN-1501;
NCIt synonyms : 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide; CDK/FLT3 Inhibitor FN-1501;
NCIt related terms : FN-1501;
NCIt definition : A small molecule multi-kinase inhibitor of cyclin-dependent kinase (CDK) subtypes
2 (CDK2), 4 (CDK4), and 6 (CDK6) and FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1),
with potential antineoplastic activity. Upon intravenous administration, CDK2/4/6/FLT3
inhibitor FN-1501 binds to and inhibits CDK2, CDK4, and CDK6, as well as FLT3. This
may induce apoptosis and inhibit tumor cell proliferation in cancer cells that overexpress
these kinases. CDKs are serine/threonine kinases that assist in cell cycle regulation
and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed
or mutated in many cancer types.;
UNII : 6MC966B505;
CAS number : 1429515-59-2;
Molecule name : FN-1501; FN 1501;
NCI Metathesaurus CUI : CL562813;
Origin ID : C155956;
UMLS CUI : C4733673;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
