Preferred Label : Inixaciclib;
NCIt synonyms : Cyclin-dependent Kinase 2/4/6 Inhibitor NUV-422; CDK2/4/6 Inhibitor NUV-422;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase (CDK) types 2 (CDK2),
4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration,
inixaciclib selectively targets and inhibits CDK2, CDK4 and CDK6, which inhibits the
phosphorylation of retinoblastoma protein (Rb) early in the G1 phase and prevents
CDK-mediated G1-S-phase transition. This leads to cell cycle arrest, the induction
of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine
kinases that are important regulators of cell cycle progression and cellular proliferation
and are upregulated in many tumor cell types. NUV-422 may be able to penetrate through
the blood-brain barrier (BBB).;
UNII : Q6460P4C0B;
CAS number : 2370913-42-9;
Molecule name : NUV 422; NUV-422;
NCI Metathesaurus CUI : CL1642598;
Origin ID : C176831;
UMLS CUI : C5447457;
Semantic type(s)
- concept_is_in_subset
- has_target
