Preferred Label : CDK2/4/6 Inhibitor RGT-419B;
NCIt synonyms : Cyclin-dependent Kinase 2/4/6 Inhibitor RGT-419B;
NCIt definition : An orally bioavailable third-generation inhibitor of cyclin-dependent kinase (CDK)
types 2 (CDK2), 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon
oral administration, CDK2/4/6 inhibitor RGT-419B selectively targets and inhibits
CDK2, CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein
(Rb) early in the G1 phase and prevents CDK-mediated G1-S-phase transition. This leads
to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell
proliferation. CDKs are serine/threonine kinases that are important regulators of
cell cycle progression and cellular proliferation and are upregulated in many tumor
cell types. In addition, RGT-419B may inhibit other kinases.;
Molecule name : RGT 419B; RGT-419B;
NCI Metathesaurus CUI : CL1794047;
Origin ID : C188891;
UMLS CUI : C5706515;
Semantic type(s)
- concept_is_in_subset
- has_target
