NCIt definition : A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential
antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent
kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition
of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent
causes cytotoxicity and prevents further tumor cell growth.;