CDK Inhibitor SNS-032

Preferred Label : CDK Inhibitor SNS-032;

NCIt related terms : SNS-032;

NCIt definition : A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth.;

UNII : 9979I93686;

CAS number : 345627-80-7;

Molecule name : BMS-387032; SNS-032;

Détails

Origin ID

C62523;

UMLS CUI

C1451099;

Currated CISMeF NLP mapping
- BMS 387032 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BMS 387032 [MeSH concept]
chemical_or_drug_affects_gene_product
- Cyclin-Dependent Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Protein Phosphorylation Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cyclin-Dependent Kinase 2 [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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