Preferred Label : CDK4/6 Inhibitor QLS12004;
NCIt definition : An inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential
antineoplastic activity. Upon administration, CDK4/6 inhibitor QLS12004 selectively
targets and inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma
protein (Rb) early in the G1 phase and prevents CDK-mediated G1-S-phase transition.
This leads to cell cycle arrest, the induction of apoptosis, and the inhibition of
tumor cell proliferation. CDKs are serine/threonine kinases that are important regulators
of cell cycle progression and cellular proliferation and are upregulated in many tumor
cell types.;
Molecule name : QLS-12004; QLS 12004;
NCI Metathesaurus CUI : CL1907554;
Origin ID : C200556;
UMLS CUI : C5854564;
Semantic type(s)
- concept_is_in_subset
- has_target
