Preferred Label : Atirmociclib;
NCIt synonyms : CDK4 Inhibitor PF-07220060;
NCIt definition : An orally bioavailable inhibitor of cyclin-dependent kinase 4 (CDK4), with potential
antineoplastic activity. Upon administration, atirmociclib selectively inhibits CDK4,
which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1
phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest.
This suppresses DNA replication and inhibits tumor cell proliferation. CDK4, a serine/threonine
kinase, is upregulated in many tumor cell types and plays a key role in the regulation
of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation.;
UNII : S743GOJ5LJ;
Molecule name : PF 07220060; PF-07220060;
NCI Metathesaurus CUI : CL1413125;
Origin ID : C175962;
UMLS CUI : C5446887;
Semantic type(s)
- concept_is_in_subset
- has_target
